Detaillierte Hinweise zur Behandlung von Opioidsucht

Detaillierte Hinweise zur Behandlung von Opioidsucht

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The safety and effectiveness of this drug hasn’t been established hinein children. It shouldn’t Beryllium used hinein children younger than 18 years.

Regardless of the dose determination strategy employed, methadone is most safely initiated and titrated using small initial doses and gradual dose adjustments.

When methadone is used with certain drugs, it may not work as well to treat your condition. This is because the amount of methadone in your body may be decreased. Examples of these drugs include:

Zidovudine – Experimental evidence demonstrated that methadone increased the area under the concentration-time curve (AUC) of zidovudine which could result hinein toxic effects.

Acute Pain – Maintenance patients on a stable dose of methadone Weltgesundheitsorganisation experience physical trauma, postoperative pain or other acute pain cannot Beryllium expected to derive analgesia from their existing dose of methadone. Such patients should Beryllium administered analgesics, including opioids, rein doses that would otherwise Beryllium indicated for non-methadone-treated patients with similar painful conditions.

Prevent theft and misuse. Keep your methadone hydrochloride tablets rein a safe place to protect them from theft. Never give methadone hydrochloride tablets to anyone else even if they have the same symptoms you have.

Methadone can also replace another opioid drug that you have an addiction to. This will keep you from experiencing severe withdrawal symptoms.

Intravenously administered naloxone or nalmefene may be used to reverse signs of intoxication. Because of the relatively short half-life of naloxone as compared with methadone, repeated injections may be required until the Stand of the patient remains satisfactory. Naloxone may also be administered by continuous intravenous infusion.

For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of methadone in your body and cause more side effects. Your doctor should watch you closely if you take this drug.

The severity of this syndrome will depend on the degree of physical dependence and the dose of the antagonist administered. If antagonists must Beryllium used to treat serious respiratory depression hinein the physically dependent patient, the antagonist should Beryllium administered with extreme care and by titration with smaller than usual doses of the antagonist.

The chance is higher if you are or have been addicted to or abused other medicines, street drugs, or alcohol, or if you have a history of mental problems.

Examples of benzodiazepines include lorazepam, clonazepam, and alprazolam. These drugs should only be used with methadone when other drugs don’t work well enough.

Although with single-dose administration the onset and duration of analgesic action, as well as the analgesic Methadontabletten 10 mg online potency of methadone and morphine, are similar methadone's potency increases over time with repeated dosing. Furthermore, the conversion ratio between methadone and other opiates varies dramatically depending on baseline opiate (morphine equivalent) use as shown in the table below.

Primary attention should be given to the reestablishment of adequate respiratory exchange through Prämie of a patent airway and institution of assisted or controlled ventilation. If a non-tolerant person, takes a large dose of methadone, effective opioid antagonists are available to counteract the potentially lethal respiratory depression. The physician must remember, however, that methadone is a long-acting depressant (36 to 48 hours), whereas opioid antagonists act for much shorter periods (one to three hours).